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KMID : 0370019920060000117
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Chung-Ang Journal of Pharmacal Sciences
1992 Volume.6 No. 0 p.117 ~ p.123
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Biopharmaceutical Studies on the Intestinal Absorption of Herbal Medicines(Ⅱ)
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So Jin-Eon
Choi Hae-Jeong
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Abstract
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The influence of bezoar on the small intestinal absorption of crude saponin in the San-Chi ginseng were studied using Schanker´s loop circulation method in situ and compared with dissolution rate and partition coefficient in vitro. It was observed that the dissolution of crude saponin in pH 6.5 phosphate buffer solution was enhanced by the addition of bezoar and reached to plateau by 60 min. And small intestinal absorption of crude saponin was also increased proportionally to the amount of bezoar added.
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